|
課程名稱 |
神經傳導
Neural Transmission |
|
開課學期 |
111-2 |
|
授課對象 |
生命科學院 生命科學系 |
|
授課教師 |
王致恬 |
|
課號 |
MCB5019 |
|
課程識別碼 |
B43 U1310 |
|
班次 |
|
|
學分 |
2.0 |
|
全/半年 |
半年 |
|
必/選修 |
選修 |
|
上課時間 |
星期四8,9(15:30~17:20) |
|
上課地點 |
生科4C |
|
備註 |
最好先修過普動及普物
總人數上限：50人 |
|
|
|
|
課程簡介影片 |
|
|
核心能力關聯 |
核心能力與課程規劃關聯圖 |
|
課程大綱
|
|
為確保您我的權利,請尊重智慧財產權及不得非法影印
|
|
課程概述 |
闡明神經細胞生物學基本觀念，主要內容為了解神經系統運作的分子細胞機制，特別著重於神經細胞內及神經細胞間的訊息傳導調控機制。教學方式以講演為主，課程中安排小組討論、隨堂筆記、論文評論作業、及期中與期末考。 |
|
課程目標 |
神經科學是二十一世紀最重要的科學之一，面對未知的事物，科學家需要妥善運用創造力和想像力。本課程旨在開發學生的原創力，挑戰學生思考與發問；訓練學生分析思辨與寫作表達的能力；提供電生理學的基本觀念；儲備未來神經科學的研究人才。 |
|
課程要求 |
英文教科書的閱讀及英文專有名詞之記憶；按照繳交作業; 預習及複習上課內容。 |
|
預期每週課後學習時數 |
2 hr |
|
Office Hours |
另約時間 備註： 每週課後或另約時間 |
|
指定閱讀 |
每週指定 |
|
參考書目 |
1. The Neuron: Cell and Molecular Biology,
Irwin B. Levitan and Leonard K. Kaczmarek,
Oxford University Press, 4th edition (2015).
E-Book purchased by NTU
(http://oxfordmedicine.com/view/10.1093/med/9780199773893.001.0001/med-
9780199773893)
2. Molecular and Cellular Biophysics,
Meyer B. Jackson,
Cambridge University Press (2006).
ISBN: 0521624703 (paperback); 052162441-X (hardback) |
|
評量方式
(僅供參考) |
|
No. |
項目 |
百分比 |
說明 |
|
1. |
隨堂筆記 |
13% |
Follow-up after lectures; Turn in homework on next Thursdays |
2. |
論文評論作業 |
25% |
1. You can pick a paper of your interest based on lecture materials. The written assignment should be concise (Note the word limit for each assignment; double space with font size 12) and should be written in Chinese or English. Select an “original” paper within 5 years from research journals (not a review article, brief communication, or comments). Turn in your choice of the original paper at the beginning of the class on the dates indicated (Specify the journal name, volume, pages, year, article title, and authors). Turn in your written assignment as a hardcopy at the beginning of the class on the date indicated.
2. Summarize the major scientific achievements for an original paper in 2 pages. Paper selection due 5/4; Due 5/25.
“Major Achievements” should cover the following points:
(1) What is the main question? Present the controversy or the unknown in the field.
(2) What is the significance or impact of this selected paper?
(3) Briefly describe the original paper. (What are the questions, methods, results, and discussions?)
(4) Can the paper address the controversy/the unknown in the field? Why?
(5) What is the impact of their work on the field? Can you explain their data in a different way? Why or why not?
(6) What is still not known?
(7) What alternative approaches can be used to address the further work?
|
3. |
期中考(Open book) |
30% |
In-class on 4/20; Open notes/books; ~100 min |
4. |
期末考(Take home) |
32% |
Take-home; due 6/08 |
|
|
針對學生困難提供學生調整方式 |
|
上課形式 |
以錄音輔助, 以錄影輔助 |
|
作業繳交方式 |
|
|
考試形式 |
|
|
其他 |
由師生雙方議定 |
|
|
週次 |
日期 |
單元主題 |
|
第1週 |
2/23 |
Introduction; Electrical properties of neurons |
|
第2週 |
3/2 |
Biophysics for neurons (I): Ohm’s Law |
|
第3週 |
3/9 |
Biophysics for neurons (II): Nernst Equation |
|
第4週 |
3/16 |
Biophysics for neurons (III): GHK Equation |
|
第5週 |
3/23 |
Ion currents |
|
第6週 |
3/30 |
Ion channels; Ionotropic receptor (I) |
|
第7週 |
4/6 |
Ionotropic receptor (II); Metabotropic receptor |
|
第8週 |
4/13 |
Review section for mid-term exam |
|
第9週 |
4/20 |
Mid-term exam |
|
第10週 |
4/27 |
Communication between neurons; Neurotransmitters and neurohormones
|
|
第11週 |
5/4 |
Techniques for studying neurotransmitter release |
|
第12週 |
5/11 |
Neurotransmitter release (I): Cellular mechanisms |
|
第13週 |
5/18 |
Neurotransmitter release (II): Molecular Mechanisms |
|
第14週 |
5/25 |
The birth and death of a neuron; Neuronal growth and axon pathfinding
|
|
第15週 |
6/1 |
Synaptic formation; Neural circuit refinement; Review section for final exam
|
|
第16週 |
6/8 |
Take-home final exam |
|